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 Biography   George K. Aghajanian, M.D. Foundations Fund Professor of Research in Psychiatry Yale University School of Medicine Dr. Aghajanian uses advanced electrophysiological technologies to study the mechanisms of chemical neurotransmission in the central nervous system. Neurotransmission involves the release of transmitter substances from pre-synaptic elements onto postsynaptic neurons. The interaction of a neurotransmitter with a postsynaptic receptor then induces either a direct change in ionic conductance or an indirect change in ionic conductance through an intermediary transducer molecule called a G protein. Dr. Aghajanian and his group study these actions through recordings from single neurons in rat-brain tissue samples. Dr. Aghajanian has been associated with Yale for nearly half a century. In addition to his studies of basic neurobiology and the neurobiology of major psychiatric disorders, he and his colleagues are examining the ways in which psychotropic drugs modify the actions of neurotransmitters. Among the drugs currently under study are antipsychotics, antidepressants, hallucinogens such as LSD and mescaline, and opiates. A member of NARSAD’s Scientific Council since 1997, Dr. Aghajanian received the Lieber Prize for Outstanding Achievement in Schizophrenia Research in 1998. |
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