Optimizing Deep Brain Stimulation for Obsessive-Compulsive Disorder

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Optimizing Deep Brain Stimulation for Obsessive-Compulsive Disorder

Circuit-based models of brain function have helped to identify neuropathologies that likely underlie certain psychiatric symptoms. Such insights have suggested highly specific targets for deep-brain stimulation, a therapy in which surgically implanted electrodes modify the activity of neural circuits thought to be involved in pathology. Treatment success, however, depends in part on personalized adjustment of DBS after the electrodes have been implanted. There is a pressing need to identify biomarkers to confirm target engagement and to guide the amount of stimulation delivered over time in specific patients. This presentation offers an overview of the advancements made and challenges faced in reaching this objective, in treatments designed to reduce symptoms of OCD.

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Presented by

Allison C. Waters, Ph.D.

Assistant Professor of Psychiatry and Neuroscience, Center for Advanced Circuit Therapeutics

Icahn School of Medicine at Mount Sinai

2019 Young Investigator Grant

Dr. Waters is a clinical neuroscientist at the Icahn School of Medicine at Mount Sinai, NY, NY. Her laboratory is embedded in the Nash Family Center for Advanced Circuit Therapeutics where the shared mission is to advance treatment with electrical neuromodulation for psychiatric and neurological disorders. Dr. Waters was a recipient of a NARSAD Young Investigator Grant for her project entitled, “A personalized cortical read-out of deep brain stimulation for obsessive-compulsive disorder.”

Moderated by

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Jeffrey Borenstein, M.D.

Brain & Behavior Research Foundation

Jeffrey Borenstein, M.D., serves as the President & CEO of the Brain & Behavior Research Foundation, the largest private funder of mental health research grants. Dr. Borenstein developed the Emmy-nominated public television program “Healthy Minds,” and serves as host and executive producer of the series. The program, broadcast nationwide, is available online, and focuses on topics in psychiatry in order to educate the public, reduce stigma and offer a message of hope. Dr. Borenstein also serves as Editor-in-Chief of Psychiatric News, the newspaper of the American Psychiatric Association.

Dr. Borenstein is a Fellow of the New York Academy of Medicine and serves as the Chair of the Section of Psychiatry at the Academy. He also has served as the President of the New York State Psychiatric Association. Dr. Borenstein earned his undergraduate degree at Harvard and his medical degree at New York University.

Optimizing Deep Brain Stimulation for Obsessive-Compulsive Disorder

Allison C. Waters, Ph.D.

Jeffrey Borenstein, M.D.

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