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 Project Summary  Janet Alder, Ph.D. (Young Investigator 2007) of Robert Wood Johnson Medical School University of Medicine & Dentistry of New Jersey (UMDNJ), will use a rodent-based model to study the brain-derived neuropeptide VGF in human depression and animal models. Dr. Alder hypothesizes that expression of the neuropeptide VGF is dysregulated in the hippocampus in human depression and that VGF acts as an antidepressant-like agent in animal models. Her ultimate goal is to design methods for detecting altered levels of VGF in patients for diagnosis of depression. Understanding how serotonin, BDNF and the molecules downstream mediate antidepressant-like effects will aid in developing novel drug targets as alternate antidepressants with faster onset of effectiveness. Program Area: MOOD DISORDERS\Mood Disorders (General) |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator