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 Project Summary  Eva Anton, Ph.D. (Staglin Investigator 2006) of University of North Carolina at Chapel Hill, will integrate results of a candidate gene for schizophrenia, neuregulin (NRG1), from a mouse model (specifically signaling and function of the gene) with human genetics. NRG1 is one of the best candidate genes for schizophrenia and is known to play critical roles in the development and patterning of the cerebral cortex. Dr. Anton will determine the NRG1-related gene expression/function changes relevant to schizophrenia and identify the cerebral cortical structural and behavioral deficits associated with NRG1 deficiency. The results from this study could yield novel targets for pharmacotherapy and other improved intervention treatments. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator