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 Project Summary  Andres Barria, Ph.D. (Young Investigator 2002) of Cold Spring Harbor Laboratory, will study the mechanisms that control the number and subunit composition of synaptic NMDA-type glutamate receptors (NMDA-Rs). The NMDA-Rs play critical roles during brain development, plasticity, and pathology, and a glutamatergic deficiency or, more specifically, a hypofunction of NMDA-Rs, has been posited to be responsible for the pathophysiology of schizophrenia. Dr. Barria is examining the normal trafficking of glutamate receptors into synapses and its modulation by synaptic activity. He will measure functional delivery of recombinant NMDA-R to synapses, examine the structural motifs on receptors involved in trafficking, and manipulate synaptic activity at different levels to study how the number and subtype of NMDA-R is controlled. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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