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 Project Summary  John L. Beyer, M.D. (Young Investigator 2003) of Duke University Medical Center, will use a technique called diffusion tensor imaging (DTI) to investigate brain structural lesions called hyperintensities, which are frequently found in patients with bipolar disorder, particular older subjects. It is hypothesized that such lesions will be associated with greater severity of depression or mania at baseline, greater cognitive dysfunction, and poorer response to treatment. Subjects will receive a brain DTI, MRI, and psychological testing, and their course will be followed naturalistically. Measures of mood severity, cognitive function, and improvement of depression with treatment will be examined in relation to the DTI findings. Program Area: MOOD DISORDERS\Bipolar\Pharmacology |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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