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 Project Summary  David J. Bucci, Ph.D. (Young Investigator 2007) of Dartmouth College, plans to study the role of a tryptophan metabolite, kynurenic acid (KYNA) that has recently been shown in large concentrations in the brains of persons with schizophrenia. Dr. Bucci hypothesizes that increased concentration of KYNA produces deficits in processes that are known to be impaired in schizophrenia: working memory, inhibition, and the ability to ignore uninformative stimuli. The findings will provide new insight into etiology of cognitive dysfunction in schizophrenia and may foster the development of novel, kynuren-ergic drug therapies. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia\Nicotine |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator