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 Project Summary  Qiang Chang, Ph.D. (Young Investigator 2008) of University of Wisconsin, Madison, will conduct a study on the molecular mechanism of Rett Syndrome (RTT), an autistic spectrum disorder that predominantly affects girls. Results from this study will not only elucidate the central role of MeCP2 in DNA methylation dependent epigenetic regulation of brain function, but also advance our understanding of the molecular mechanism of Rett syndrome. Furthermore, because the considerable overlap in clinical features between RTT and autistic spectrum disorders, the lessons learned studying RTT may also benefit the general understanding of autism. Program Area: PERVASIVE DEVELOPMENTAL DISORDERS\Rett’s Disorder |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator