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Ali Charara, Ph.D. (Young Investigator 2002) of University of Pittsburgh, is studying the mechanisms underlying information processing in the nucleus accumbens, which may be involved in the pathophysiology of schizophrenia. Dr. Charara will utilize electrophysiological recording techniques in vitro to examine the modulation by dopamine of the amygdala and hippocampus-evoked responses in the nucleus accumbens. He will focus on the dopamine receptor subtype involved and compare the results in normal rats with those in a developmental disruption model of schizophrenia. The project will provide valuable new information relevant for understanding the role of the nucleus accumbens in the pathophysiology of schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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