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Gabriella D'Arcangelo, Ph.D. (Young Investigator 2002) of Baylor College of Medicine, will study the biological activity of Reelin at the cellular and molecular level. Reelin is an extracellular protein developmentally regulated in the brain. Post-mortem brains of patients with schizophrenia and bipolar disorder display a reduced expression of Reelin, which might indicate the presence of a predisposing factor towards schizophrenia and bipolar disorders. Dr. D'Arcangelo hopes to elucidate a potential cellular mechanism that may be altered in schizophrenia, which could lead to further studies designed towards prevention and a cure. Program Area: MULTIPLE FOCUS AREAS\Schizophrenia/Bipolar |
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