Project Summary

Ayman Fanous, M.D. (Young Investigator 2000) of Virginia Commonwealth University, is conducting two approaches aimed at isolating genes that increase the vulnerability to schizophrenia.  The first is called the Quantitative Trait Loci (QTL) method, which attempts to correlate the similarity in the symptoms of an illness with similarities in the genes.  Haplotype analysis is a method based on the assumption that a disease gene is surrounded by other fragments of the ancestral chromosome on which the original mutation occurred.  The study will utilize data collected on a large study of families with multiple family members affected with schizophrenia.  This work may lead to identification of one or more genes for schizophrenia.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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