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 Project Summary  Yue Feng, Ph.D. (Independent Investigator 2007) of Emory University, is investigating the role of the protein QKI in the cognitive impairment of schizophrenia. Axons, extensions from nerve cell, conduct the brain’s messages. Myelin, the material that insulates axons, ensures rapid axonal conduction in the brain. Reduction of myelin structural gene expression is observed in postmortem schizophrenic brain tissue, suggesting that aberrant development and/or maintenance of myelin may contribute to the functional disconnectivity in schizophrenia. The QKI gene, which appears to be essential for myelination, is a new candidate for involvement in schizophrenia. In studying QKI, Dr. Feng’s goal is to delineate the pathological consequence of myelin defects and the effects of antipsychotic drugs on myelination. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator