Project Summary

Roman J. Giger, Ph.D. (Young Investigator 2002) of University of Rochester, will attempt to understand and characterize molecules that are known to be critically involved in neural network assembly and brain development.  Based on a novel and powerful gene engineering strategy he intends to modulate such molecules to uncover their role during the assembly of complex neural networks.  Growing evidence suggests that subtle abnormalities in the assembly of neural networks which mediate complex cognitive functions can lead to severe neuronal deficits and disease, including schizophrenia.  Dr. Giger believes that a better understanding of the molecular and cellular mechanisms that regulate fundamental developmental processes will provide new insights into the etiology of brain illness, including psychiatric disorders such as schizophrenia.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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