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 Project Summary  Nathalie Ginovart, Ph.D. (Young Investigator 2000) of Centre For Addiction and Mental Health, is investigating the mechanisms that may lead to tardive dyskinesia, a potentially irreversible condition of involuntary movements that can occur following chronic treatment with antipsychotics. Tardive dyskinesia is believed to arise from a phenomenon called dopamine-type 2 (D2) receptor up-regulation. In this project, the effect of transient versus continuous and high versus low D2 receptor blockade will be examined in the brains of cats. It is hypothesized only continuously high D2-receptor blockade will cause receptor up-regulation. This study may have implications for safer and more tolerable treatments for schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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NARSAD Award Winners
 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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