Project Summary

David C. Glahn, Ph.D. (Young Investigator 2003) of University of Texas Health Science Center at San Antonio, using functional magnetic resonance imaging (fMRI), will examine the neural architecture of contextual processing within the dorsolateral prefrontal cortex (DLPFC).  The ability to process contextual information is often impaired in patients with schizophrenia.  Dr. Glahn will assess the ability of patients and healthy controls to utilize contextual information to improve the performance of working memory.  He predicts that the schizophrenia subjects will be less able to utilize valid contextual information to enhance working memory as evidenced by poorer performance and less DLPFC activation. 

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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