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 Project Summary  Chang-Gyu Hahn, M.D., Ph.D. (Young Investigator 2000) of University of Pennsylvania, is investigating abnormal physiologic mechanisms in patients with bipolar disorder, using nerve cells that detect olfaction (the sense of smell). Previous work suggests abnormalities in the regulation of calcium levels within these olfactory cells in bipolar patients. In this study, the odorant induced calcium response in these neurons will be characterized in depressed, hypomanic and/or manic, and euthymic bipolar patients. By applying sophisticated molecular techniques, gene regulation can be examined in the olfactory neurons. This study may hold promise for a better understanding of abnormal signaling mechanisms that may underlie bipolar disorder. Program Area: MOOD DISORDERS\Bipolar |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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