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Ahmad R. Hariri, Ph.D. (Young Investigator 2003) of University of Pittsburgh, has found that individuals with a low-activity version of the serotonin transporter gene (associated with increased synaptic concentrations of serotonin) exhibit amygdala hyperexcitability to fearful stimuli. This may underlie the increased prevalence of fearfulness, anxiety and affective illness previously associated with these individuals. Dr. Hariri proposes to explore the influence of this variation on the interplay of distinct brain regions involved in the regulation of emotional behavior as well as the interactions of this genetic variation in the serotonin system with those in other brain neurotransmitter systems including dopamine. Program Area: ANXIETY DISORDERS\Post-Traumatic Stress Disorder (PTSD) |
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