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Felix Hasler, Ph.D. (Young Investigator 2004) of Psychiatric University Hospital, Zurich, seeks to elucidate the mode of interaction of serotonergic 5-HT1A and 5-HT2A receptors in humans by exploring the effects of psilocybin, a 5HT2A agonist. The functional integrity of 5-HT2A and 5-HT1A serotonin (5-HT) receptors is crucial in the pathophysiology of schizophrenia. Dr. Hasler hypothesizes that it is conceivable that partial 5-HT1A agonists may ameliorate psychotic symptoms and cognitive deficits in schizophrenic psychoses. He will attempt to understand the mode of interaction of serotonergic 5-HT1A and 5-HT2A receptors in humans and its basic and clinical implications. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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