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Susan Ingram, Ph.D. (Young Investigator 2000) of Oregon Health and Sciences University, will characterize the electrophysiological properties of dopamine transporter (DAT) currents in midbrain dopamine nerve cells, and determine whether these currents play a role in the regulation of neurotransmitter signaling in the midbrain. The DAT enables uptake of dopamine from the space between neurons, and cause electrical currents that could increase the excitability of neurons. Characterization of these electrical currents on neurotransmitter release may provide new insights into the pharmacological action of antipsychotic medications. Program Area: MULTIPLE FOCUS AREAS\Schizophrenia/Bipolar |
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