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 Project Summary  Samie R. Jaffrey, M.D., Ph.D. (Young Investigator 2002) of Weill Medical College of Cornell University, will investigate the role of nitric oxide (NO) in N-methyl-D-aspartate receptor (NMDAR) signaling, by using a novel assay he developed to detect and purify proteins which have been S-nitrosylated. Abnormalities in NMDAR signaling may have a role in the etiology of schizophrenia. He will use this assay to identify the major nitrosylated proteins in brain membranes and visualize the activation of NO signaling pathways in brain slices derived from animal models of schizophrenia. These studies will provide insight into determining the role of NO in schizophrenia and will elucidate how NO mediates the actions of psychomimetic and antischizophrenic drugs. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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