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Nadine Jarousse, Ph.D. (Young Investigator 2000) of University of California, San Francisco, is researching how lack of a class of vesicles (organelles that contain neurotransmitters) could give rise to certain neurological symptoms in mutant mice. This mutant, called “mocha,” is missing a brain-specific form of a protein (nAP3) needed to form synaptic vesicles, required for the release of neurotransmitters. This work may have applications to panic disorder, because one of the features of these mutant mice is an unusual sensitivity to low levels of carbon dioxide. Program Area: ANXIETY DISORDERS\Panic Disorder |
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