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 Project Summary  Bjorn Johansson, M.D., Ph.D. (Young Investigator 2007) of Karolinska Institute, will apply a specialized form of mass spectrometry to study the effects of lithium on cell lipids. Lithium is an effective treatment for bipolar disorder, but its mechanism of action is not well understood. Evidence indicates that lithium has brain lipids (fatty substances) as one target, and that the genesis of bipolar disorder may involve lipid disturbances. Localization of lithium in brain cells may help pinpoint its site of action. Imaging of specific lipids at different locations in brain tissue will help pinpoint lithium’s effect on them. This research may also provide new information about lipid disturbances in bipolar disorder in the absence of lithium treatment. Program Area: MOOD DISORDERS\Bipolar |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator