Project Summary

Rachel Jurd, Ph.D. (Young Investigator 2008) of University of Pennsylvania, plans to delineate how GABAAR ubiquitination is regulated in vivo. Recent studies have suggested that there is a reduction in signaling through a2-containing GABAA receptors (GABAARs) in schizophrenia. Thus, treatments that selectively modulate GABAARs are likely to be of therapeutic value. If GABAAR function can be upregulated by selectively manipulating the levels of ubiquitination, it might have considerable therapeutic implications for schizophrenia, in which there is an underlying hypofunction in GABAergic signaling.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS

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