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 Project Summary  Rima F. Kaddurah-Daouk, Ph.D. (Independent Investigator 2005) of Duke University Medical Center, plans to use the latest genomics technologies to study the lipid profile of individuals with schizophrenia before and after treatment with three antipsychotic drugs, Risperidone, Olanzapine, or Aripiprazole. Dr. Kaddurah-Daouk hypothesizes there are biochemical changes in lipid metabolism in patients with schizophrenia that are long-lasting and that can be picked up in the plasma; that additional biochemical changes in lipid metabolism occur upon treatment with antipsychotic drugs and that these biochemical changes will disclose information about the pathophysiological mechanisms involved in schizophrenia and will provide insights about metabolic effects of antipsychotic drugs. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator