Project Summary

Theodore S. Kalbfleisch Ph.D. (Young Investigator 2006) of the University of Louisville, aims to develop a Web-based system to enhance finding genes associated with schizophrenia. Schizophrenia is a genetically complex disease, which means it involves a large number of genes with small effects. Comprehensive association studies for this disease may require analysis of tens to hundreds of genes for hundreds of patients. Data management is a significant problem in studies of this size and breadth. In the proposed project, Dr. Kalbfleisch plans to develop a Web-based system that will support all phases of biomarker discovery: 1) the mining of public domain data sources for single nucleotide polymorphisms (SNPs), insertion-deletions (IN/DELs), and short tandem repeats (STRs), and their associated genotype data; 2) the export of genomic context for genotyping assay design; and 3) the analysis of the resulting genotype data, including haplotype construction, and the association of phenotype data with this genotype and haplotype data for statistical analysis and biomarker discovery

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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