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 Project Summary  Eric R. Kandel, M.D. (Distinguished Investigator 2000) of Columbia University, is undertaking a new series of studies on the molecular mechanisms in the amygdala that govern the learned acquisition of anxiety, and the delineation of genes recruited during the acquisition of fear. Context conditioning of fear will be examined as a model of chronic anxiety and cued conditioning of fear as a model of anticipatory anxiety. The function of genes expressed during these two types of anxiety states will be determined using methods for regional gene expression restricted to the amygdala, behavioral analysis, and analysis of a phenomenon known as long-term potentiation in the amygdala. This work has promise for elucidating the neural circuits and genes that cause anxiety disorders. Program Area: ANXIETY DISORDERS |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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