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 Project Summary  Tadafumi Kato, M.D. (Independent Investigator 2000) of Brain Science Institute, will examine whether abnormalities of calcium regulation in a cellular organelle called mitochondria occur in patients with bipolar disorder. The mitochondria are the energy-producing components of the cell. Based on previous work, it is hypothesized that mitochondrial dysfunction causes increased levels of calcium and increased vulnerability to cell death, leading to rapid-cycling in bipolar disorder. Cell lines produced from platelets and the olfactory mucosa (the tissue responsible for the sense of smell) will be immortalized, and biochemical processes causing an enhanced calcium response in bipolar patients will be investigated. This work has the potential to result in new medications which improve the symptoms of bipolar disorder by reversing abnormalities of calcium regulation. Program Area: MOOD DISORDERS\Bipolar |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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