Project Summary

Wesley K. Kroeze, Ph.D. (Young Investigator 2004) of Case Western Reserve University, notes that weight gain for people with schizophrenia from atypical antipsychotic drugs can be life-threatening, limiting their potential use. Dr. Kroeze has evidence that drugs that lead to weight gain have high affinity for H1 histamine receptors, alpha-1A adrenergic receptors and 5-HT2 receptors. In his proposed study, he plans to look at more drugs and more receptors, which have a connection to feeding behavior. He has devised a high-throughput novel fluorescence-based assay to detect drug binding to receptors. Results should lead to a better understanding of why some drugs cause weight gain and possible new drugs that do not have this property.

Program Area: MULTIPLE FOCUS AREAS\Mood Disorders/Schizophrenia

Search Again