Project Summary

Hui-Chen Lu, Ph.D. (Young Investigator 2008) of Baylor College of Medicine, seeks to determine the role of GPR55, a member of the G-protein coupled receptor superfamily, in neural development and synaptic plasticity in neural networks. In adult brains, GPR55 is expressed in brain areas known to be involved in addictive processes and cognitive functions. The prominent expression of GPR55 in the striatum suggests a role in mediating cannabinoid signaling in addiction-related processes and motor function. It has been suggested that in utero cannabis exposure affects neural development and consumption of marijuana during pregnancy can lead to offspring with impulsive behavior, cognitive impairment, and psychiatric disorders. Results from this study should help to determine the role of GPR55 in CNS function and direct future therapeutic strategies for treatment of drug use or various psychiatric disorders.

Program Area: ADDICTION/SUBSTANCE-RELATED DISORDERS

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