Project Summary

Rajnish Mago, M.D. (Young Investigator 2006) of Thomas Jefferson University, will study whether the drug terazosin, an alpha-1-receptor blocker, will reduce the sweating side-effect seen with certain antidepressant usage. The proposed project has two phases. First, 20 patients with excessive sweating due to an antidepressant will wear a device to measure sweating. Second, patients will take terazosin, which Dr. Mago hypothesizes will reduce sympathetic nervous system activity and reduce sweating. He will measure the sympathetic nervous system activity by assaying urine catecholamine levels. He will then assess whether the degree of sweating and the degree of improvement with terazosin are correlated with urinary catecholamine levels. If treatment of antidepressant-induced excessive sweating with terazosin works, it may improve medication adherence in depressed patients and also be helpful for excessive sweating due to other reasons.

Program Area: MOOD DISORDERS\Unipolar

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