Project Summary

Hari Manev, M.D., Ph.D. (Independent Investigator 2000) of University of Illinois, Chicago, will investigate whether antidepressants can be used as a tool to elucidate the mechanisms of neurogenesis (new nerve cell growth). It has been previously demonstrated that antidepressants such as fluoxetine can stimulate the growth of new neurons. Dr. Manev will characterize the action of antidepressants on neurogenesis in cultured neurons of rats; investigate whether these effects can be induced after birth; characterize the selectivity of antidepressants in stimulating cell proliferation in the adult hippocampus; and characterize the contribution of serotonin to hippocampal proliferation induced by fluoxetine. This work promises to contribute significantly to understanding the pathophysiology of depression and other psychiatric disorders.

Program Area: MOOD DISORDERS\Mood Disorders (General)

Search Again