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 Project Summary  Helene Marie, Ph.D. (Young Investigator 2007) of the European Brain Research Institute (Rome, Italy), aims to elucidate the long-term neuronal effects of chronic antidepressant treatment. Chronic treatment with virtually all antidepressants increases levels of a transcription factor called CREB in the hippocampus, a brain structure implicated in depression. Previous studies in Dr. Marie’s laboratory showed that artificially expressed CREB in rat hippocampal neurons led to an increase in receptors for the neurotransmitter glutamate and increased neuron excitability. The lab will now test to see if the rats respond similarly to the antidepressant fluoxetine (Prozac). Program Area: MOOD DISORDERS\Mood Disorders (General) |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator