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 Project Summary  Christine Elizabeth Marx, M.D. (Young Investigator 2000) of Duke University, is quantifying levels of neurosteroids in autopsied brains, and cerebrospinal fluid of patients with schizophrenia. Neurosteroids are hormones that have profound effects on the brain during neurodevelopment and adulthood in both men and women. It is thought that some antipsychotics act via altering levels of neurosteroids. Dr. Marx will measure levels of several neurosteroids, including allopregnanolone, dehydroepiandrosterone (DHEA), and its derivative DHEAS, in brain specimens, and compare these levels between brains of patients with schizophrenia, bipolar disorder, depression, and controls. In addition neurosteroid levels will be measured in cerebrospinal fluid before and after treatment in patients with schizophrenia. This work may provide evidence that neurosteroids or related compounds have potential in the treatment of schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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