Project Summary

Jennifer G. Mulle, Ph.D. (Young Investigator 2007) of Emory University, will conduct one of the first large-scale examinations of a type of variation in DNA that contributes to schizophrenia. The variation involves deletion or duplications of stretches of DNA. Her laboratory will examine this phenomenon, called copy number variation, in scans of the genomes of 1,000 unrelated Ashkenazi Jewish cases and controls and 600 parents of schizophrenia patients. Although schizophrenia is not more common to this group than the general population, its relative isolation reduces heterogeneity, thereby easing analysis.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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