Project Summary

Gretchen N. Neigh, Ph.D. (Young Investigator 2007) of the Emory University School of Medicine, will investigate the underlying neurobiology of late-life depression that is associated with vascular disease. Evidence of mini-strokes in the brain is correlated with depression in the elderly, but it is unknown whether vascular changes are involved or are an unrelated but co-occurring event. Using a rat model, Dr. Neigh and her colleagues will seek to determine if multiple mini-strokes cause depression, and whether stress increases depression following mini-strokes. Magnetic resonance imaging will be used to identify size and location of brain tissue damaged by the strokes. This information will be compared with information collected from human patients.

Program Area: MOOD DISORDERS\Unipolar\Cardiovascular Disease

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