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Erik B. Nelson, M.D. (Young Investigator 2003) of University of Cincinnati, will assess the relationship between the hormonal stress (HPA) axis and melancholic and atypical symptoms in patients with depression. It is hypothesized that elevated stress hormone activity in depression is associated with increased arousal and anorexia seen in the melancholic subtype of depression, while low stress hormone activity is related to symptoms of fatigue and increased appetite in atypical depression. For this purpose, 30 patients with major depression, 15 with each depression subtype, will undergo a series of HPA axis tests including the measurement of urinary cortisol, plasma cortisol, and ACTH levels. Program Area: MOOD DISORDERS\Depression (Unipolar) |
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