Project Summary

Alexander B. Niculescu, M.D., Ph.D. (Young Investigator 2002) of University of California, San Diego, will use a mouse animal model to assess gene changes following methamphetamine administration, as well as what happens in the brain of mice after treatment in terms of brain plasticity and re-modeling.  Previously, Dr. Niculescu used a rat model which revealed some interesting genes possibly involved in manic-depressive illness, schizophrenia, and drug abuse.  He now plans to extend his studies to mice, as most of the mouse genome has been sequenced and mice can have their DNA engineered by inserting or deleting genes.  Ultimately, he would like to correlate changes in genes with the re-modeling and with the behavior of those mice.  He believes such an integrated approach may provide new insights into the mechanisms of psychotic illnesses and drug abuse.  This may in turn point to new avenues for treatment.

Program Area: MULTIPLE FOCUS AREAS\Psychotic Disorders/Bipolar/Addiction

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