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 Project Summary  Jose' N. Nobrega, Ph.D. (Independent Investigator 2000) of Centre For Addiction and Mental Health, is investigating whether alterations in non-dopaminergic receptors play a role in long-term side effects of antipsychotic medications. These side effects include tardive dyskinesia and can be tested in animal models by observing vacuous chewing movements (VCM). Dr. Nobrega will screen hundreds of genes to identify those that may be specifically associated with VCM vulnerability. Then, he will determine whether VCM and the accompanying gene alterations develop in mice lacking specific subtypes of dopamine receptors. This study should provide new and possibly fundamental important information about the nature of brain changes responsible for tardive dyskinesia and the role of dopamine receptors in that process. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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