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 Project Summary  Yamima Osher, Ph.D. (Young Investigator 2003) of Beer Sheva Mental Health Center, is studying the level of homocysteine in the brain of bipolar patients. Dr. Osher believes that bipolar patients will have a higher level of homocysteine levels than controls, and that these levels will be related to neurocognitive defects. Homocysteine has been shown to be neurotoxic and it has been shown that stress can open the blood brain barrier to some neurotoxic substances. It is possible that stress of acute psychosis allows high homocysteine levels to enter the brain, resulting in neurodegeneration, clinical deterioration and chronicity. If true, this could be critical for the treatment of neurodeterioration, as folic acid and vitamin B-12 can markedly reduce plasma homocysteine and might actually ameliorate the neurodegeneration. Program Area: MOOD DISORDERS\Bipolar |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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