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 Project Summary  David M. Raizen, M.D., Ph.D. (Young Investigator 2003) of University of Pennsylvania, is developing a model system for the study of sleep and circadian rhythms, using the nematode (worm) C. elegans. Disruptions of sleep and circadian rhythms (behaviors and physiologic processes that are controlled by an “internal clock”) frequently characterize psychiatric disorders. Dr. Raizen will refine behavioral measurements of circadian rhythms in C. elegans, using a video camera attached to a microscope in a temperature-controlled dark room. Then, the circadian behavior of C. elegans with a mutation in a specified gene will be examined. Program Area: MULTIPLE FOCUS AREAS\Mood Disorders/Schizophrenia/Sleep Disorders |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator