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 Project Summary  Neil M. Richtand, M.D., Ph.D. (Young Investigator 2000) of University of Cincinnati, is testing whether downregulation of dopamine type 3 (D3) receptor function plays a role in a phenomenon called “sensitization.” The behavioral changes of sensitization are mediated by brain pathways that play an important role in schizophrenia and bipolar disorder. Dopamine's behavioral effects depend upon which receptor subtype, or balance between receptor subtypes, is stimulated. This work has several important implications, including the potential use of D3 dopamine receptor blockers in prodromal phases of schizophrenia; and the elucidation of D3 dopamine receptor-associated regulatory mechanisms, which could be targets for antipsychotic medication treatments. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator