Project Summary

Gregg Roman, Ph.D. (Young Investigator 2003) of Baylor College of Medicine, will study improper G-protein receptor (GPCR) signaling within the nervous system which may play a significant role in the development of illnesses such as schizophrenia, depression and addiction.  GPCR's are responsible for the transfer many neurotransmitter and neuromodulator signals.  Proteins known as arrestins carry out the inhibition of activated G-protein signaling.  These arrestins are also required to reactivate GPCR's.  Dr. Roman plans to study the single arrestin in the fruit fly, known as “Kurtz”, in order to identify new genetic mutations that will provide insight into the mechanisms for overcoming maladaptive G-protein signaling.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS

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