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 Project Summary  Randall R. Sakai, Ph.D. (Independent Investigator 2000) of University of Cincinnati, will investigate the hormone, brain chemical, and brain structural profile of animals exposed to prolonged stress. Recent studies suggest a valid animal model of clinical depression which makes use of a visible burrow system. Animals in this system have reduced social, sexual, and aggressive activity, changes in sleep cycles, and weight loss associated with lower food intake. In addition, nerve cells in the hippocampus of animals in this system undergo “remodeling” similar to that of animals which receive chronic doses of stress hormones. This proposal attempts to better understand this remodeling process as well as ascertain whether it occurs with concurrent changes in cell birth or death. Program Area: MOOD DISORDERS\Bipolar |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator