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 Project Summary  Ratna Sircar, Ph.D. (Independent Investigator 2001) of Albert Einstein College of Medicine of Yeshiva University, will attempt to find candidate genes for schizophrenia by using the cDNA microarray technology. Microarrays are useful because they allow a quantitative analysis of expression of thousands of genes within a sample at the same time and under identical conditions. Dr. Sircar will identify and monitor gene expression profile changes in postmortem schizophrenic and normal brain specimens, focusing on the prefrontal cortex area. The study hopes to demonstrate the functional aspects of the cDNA microarray technology in analyzing the molecular changes that occur in schizophrenia, and in identifying new molecular pathways involved and an increased understanding of these processes will lead to enhanced diagnosis and intervention efforts in the future. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator