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 Project Summary  Kirsty L. Spalding, Ph.D. (Young Investigator 2007) of Karolinska Institute, is investigating evidence from animal studies that abnormalities in brain cells generated during adulthood might be involved in schizophrenia and mood disorders. Dr. Spalding and colleagues have developed a way to study cell turnover in humans, which has previously been a problem. The technique involves isolating the brain region of interest, sorting for the particular nerve cells of interest, and extracting and carbon-dating the cells’ DNA. The method will be used to assess where -- and whether -- new nerve cells are added in the human brain, and whether schizophrenia, bipolar disorder and depression are associated with aberrations in their neurogenesis. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator