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 Project Summary  Steven T. Szabo, Ph.D. (Young Investigator 2003) of National Institute of Mental Health (NIMH/NIH), is investigating a family of proteins called Homer with regard to their role in the mechanisms of action of antidepressant. It is proposed that antidepressants cause alterations of Homer, which produce structural changes and enhanced cellular resilience in critical neuronal circuits important for sustaining mood. The effects of acute and chronic antidepressants on Homer and glutamate receptor expression in discrete brain areas will be examined. In addition, the cellular localization of these effects will be ascertained. Furthermore, the behavioral relevance of these findings will be examined in mouse models of depression. Program Area: MOOD DISORDERS\Depression (Unipolar)\Pharmacology |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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