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 Project Summary  Frank I. Tarazi, Ph.D. (Young Investigator 2000) of McLean Hospital, aims to quantify the distribution and density of NMDA receptors, nitric oxide synthase, and associated proteins in autopsied brains of patients with schizophrenia. Both the NMDA receptor and nitric oxide synthase have been implicated in schizophrenia; these two proteins interact with one another. Animal model experiments conducted in parallel will examine long-term effects of a typical antipsychotic and selected atypical antipsychotics on levels of NMDA receptors. This work may stimulate new hypotheses concerning the role of these proteins in the pathophysiology of schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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