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 Project Summary  Jane R. Taylor, Ph.D. (Independent Investigator 2000) of Yale University School of Medicine, will investigate the neurobiological underpinnings of cognitive impulsivity. The hypothesis to be tested is that cortical dopamine dysfunction, induced by prior long-term exposure to PCP (“angel dust”) or amphetamine, will produce cognitive impulsivity (deficits in response control, attentional function, and working memory). Alterations in dopamine transmission, and in an enzyme essential for the response elicited by dopamine receptor stimulation, will be examined in relation to cognitive impulsivity. This model system may have important implications for better understanding the biological abnormalities that underlie schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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