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 Project Summary  Steven A. Thomas, M.D., Ph.D. (Young Investigator 2001) of University of Pennsylvania, is using a mouse model to investigate the role of norepinephrine in depression. He has developed a mouse model in which norepinephrine has been completely eliminated. The mutant mice will be tested for behaviors that predict the effectiveness of antidepressants, including learned helplessness, behavioral despair, and chronic unpredictable stress. The ability of various antidepressants to reverse signs of behavioral depression will also be measured. These experiments may help determine whether effects on the norepinephrine system should be considered in the development of new antidepressants. Program Area: MOOD DISORDERS\Depression (Unipolar) |
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NARSAD Award Winners
 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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