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Project Summary

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Catherine C. Thompson, Ph.D. (Young Investigator 2001) of Kennedy Krieger Institute, is identifying regions of the brain in which genes are activated by thyroid hormone.  Numerous studies have linked thyroid hormone deficiency to depression.  This will be accomplished using mice that carry a genetically engineered gene, which is activated only in the presence of thyroid hormone.  This will permit the discovery of where in the brain thyroid hormone-responsive genes are turned on.  These sites will then become the focus of further studies to identify specific genes that are regulated by thyroid hormone, and test the effect of antidepressant medications on these genes.

Program Area: MOOD DISORDERS\Unipolar/Bipolar

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Announcements
2008/2009 NARSAD Grant Deadlines:

2008 Independent Investigator application deadline: March 5, 2008

2008 Young Investigator, 2008 Distinguished Investigator and 2008 Staglin Grantees Announced: March, 2008

2008 Distinguished Investigator Earliest Start Date: May 1, 2008

2009 Distinguished Investigator Award application deadline: May 15, 2008

2008 Young Investigator Earliest Start Date: July 1, 2008

2009 Young Investigator Award application deadline: July 25, 2008

2008 Independent Investigator Award Earliest Start Date: September 15, 2008

2008 Staglin Award Earliest Start Date: September 15, 2008

2009 Distinguished Investigator Earliest Start Date: May 1, 2009

2009 Young Investigator Earliest Start Date: July 1, 2009





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